Journal of Indian Academy of Oral Medicine and Radiology

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 28  |  Issue : 2  |  Page : 140--144

Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study


Anand Choudhary1, Pallavi Kesarwani2, Pravin Gaikwad3, Santhosh S Hiremath4, Renuka Gupta5, Sri Krishna Koppula1 
1 Department of Oral Medicine and Radiology, Hazaribag College of Dental Sciences, Hazaribag, Jharkand, India
2 Department of Oral Pathology and Microbiology, Hazaribag College of Dental Sciences, Hazaribag, Jharkand, India
3 Department of Oral Pathology and Microbiology, Sukhmani Dental College, Dera Bassi, Punjab, India
4 Department of Oral Pathology and Microbiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India
5 Department of Oral Pathology and Microbiology, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India

Correspondence Address:
Pallavi Kesarwani
Flat No. 2A Savitri Appartment, Harihar Singh Road, Morabadi, Ranchi - 834 008, Jharkhand
India

Introduction: Cyclin D1 oncogene is a key regulator of cell cycle progression associated with various human malignancies. Aim: To establish the prognostic significance of cyclin D1 in oral squamous cell carcinoma (OSCC) and to correlate its association with clinicopathological parameters. Materials and Methods: A retrospective study was carried out on 50 previously histopathologically diagnosed, formalin-fixed, paraffin embedded (FFPE) tissue samples of OSCC. Immunohistochemical analysis was performed in 50 cases of different grades of OSCC using a commercially available monoclonal anti-cyclin D1 antibody. Statistical Analysis Used: All the compiled data was statistically analyzed using Chi-square and Mann-Whitney test. P values of <0.05 were considered to be significant. Results: Overexpression of cyclin D1 was seen in 68% cases of OSCC with a significant correlation with younger age group; no correlation was reported with respect to gender and site. The intergroup comparison of the cyclin D1 expression between well with poorly differentiated OSCC exhibited a significant correlation. Conclusions: The relative contribution of cyclin D1 expression in OSCC was significant according to the present study and further needs to be determined in large cohorts.


How to cite this article:
Choudhary A, Kesarwani P, Gaikwad P, Hiremath SS, Gupta R, Koppula S. Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study.J Indian Acad Oral Med Radiol 2016;28:140-144


How to cite this URL:
Choudhary A, Kesarwani P, Gaikwad P, Hiremath SS, Gupta R, Koppula S. Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study. J Indian Acad Oral Med Radiol [serial online] 2016 [cited 2022 Dec 8 ];28:140-144
Available from: http://www.jiaomr.in/article.asp?issn=0972-1363;year=2016;volume=28;issue=2;spage=140;epage=144;aulast=Choudhary;type=0