Association of vitamin D serum concentration and oral lichen planus: A randomized controlled clinical trial

Vinaya R Pawar; Sowmya Krishna; TA Deepak; GA Prarthana; Supriya Vyavahare; Rashmi D Jujare

doi:10.4103/jiaomr.jiaomr_216_21

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ORIGINAL ARTICLE

Year : 2022 | Volume : 34 | Issue : 4 | Page : 414-417

Association of vitamin D serum concentration and oral lichen planus: A randomized controlled clinical trial

Vinaya R Pawar¹, Sowmya Krishna², TA Deepak², GA Prarthana³, Supriya Vyavahare⁴, Rashmi D Jujare⁵
¹ Department of Oral Medicine and Radiology, Shri. Yashwantrao Chavan Dental College, Ahmednagar, Maharashtra, India
² Department of Oral Medicine and Radiology, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India
³ Department of Oral Medicine and Radiology, Rajarajeshwari Dental College, Bengaluru, Karnataka, India
⁴ Department of Public Health Dentistry, Shri. Yashwantrao Chavan Dental College, Ahmednagar, Maharashtra, India
⁵ Department of periodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Vinaya R Pawar
14, “Ashay”, Bhagyalaxmi Nagar, Vasmat Road, Parbhani, Maharashtra
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jiaomr.jiaomr_216_21

Introduction: Vitamin D plays a crucial role in regulating immunity by reducing the multiplication of helper T cells, activating regulatory T cells, and inhibiting the release of immunoglobulins. Vitamin D levels must be measured in a disease mediated by the immune system, such as oral lichen planus (OLP). Aim: This study aimed to identify the potential association between vitamin D serum levels and OLP. Material and Methods: A randomized case-control study was conducted with 50 volunteers divided into two groups: 20 case subjects and 30 controls. 2.5 ml of venous blood was extracted from the median cubital vein of both patients and controls. The total quantity of 25-hydroxyvitamin D was determined by an electrochemiluminescence binding assay. Statistical Analysis Used: The independent student's t-test was performed to compare the serum vitamin D levels between the two groups. Results: The mean vitamin D values in OLP patients and healthy controls were 15.11 and 26.10 ng/ml, respectively. In OLP cases, vitamin D3 deficiency was more prevalent than in control subjects. These distinctions were statistically significant (P-value < 0.05). Conclusion: Vitamin D levels might portray a significant factor in the aetiopathogenesis of OLP and could influence the disease's course and prognosis.

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