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Year : 2022  |  Volume : 34  |  Issue : 4  |  Page : 409-413

Comparison of efficacy of topical application of bleomycin with adjuvant antioxidants vs. Topical curcumin oral gel with adjuvant antioxidants in the treatment of oral leukoplakia

Department of Oral Medicine and Radiology, Tamilnadu Government Dental College And Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
A I Samu Fathima
No. 37, Raju Street, West Mambalam, Chennai.33, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jiaomr.jiaomr_201_22

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Introduction: Oral leukoplakia (OL) is an oral premalignant disorder (OPMD) defined as a white plaque of questionable risk, and the diagnosis is by exclusion. Aim: We aimed to compare the effectiveness of topical bleomycin with that of topical curcumin in patients with oral leukoplakia (OL). Materials and Methods: Bleomycin was assigned for group A and curcumin for group B patients. Both the drugs were applied topically with adjuvant oral antioxidants for both groups. Results: Group A (n = 10) patients showed partial to complete resolution of the leukoplakic lesions with a P value of 0.01, whereas in group B (n = 10) patients, resolution of the clinical lesion was not substantial, but a reduction of the erythroid component was observed along with histopathological improvement of dysplasia with a P value of 0.01. Conclusion: Comparatively, bleomycin was more efficient in producing clinical and histopathologic resolution of OL than curcumin.

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