| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 34
| Issue : 4 | Page : 409-413 |
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Comparison of efficacy of topical application of bleomycin with adjuvant antioxidants vs. Topical curcumin oral gel with adjuvant antioxidants in the treatment of oral leukoplakia
A I Samu Fathima, G V. Murali G. Manoharan
Department of Oral Medicine and Radiology, Tamilnadu Government Dental College And Hospital, Chennai, Tamil Nadu, India
Correspondence Address:
A I Samu Fathima
No. 37, Raju Street, West Mambalam, Chennai.33, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jiaomr.jiaomr_201_22
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Introduction: Oral leukoplakia (OL) is an oral premalignant disorder (OPMD) defined as a white plaque of questionable risk, and the diagnosis is by exclusion. Aim: We aimed to compare the effectiveness of topical bleomycin with that of topical curcumin in patients with oral leukoplakia (OL). Materials and Methods: Bleomycin was assigned for group A and curcumin for group B patients. Both the drugs were applied topically with adjuvant oral antioxidants for both groups. Results: Group A (n = 10) patients showed partial to complete resolution of the leukoplakic lesions with a P value of 0.01, whereas in group B (n = 10) patients, resolution of the clinical lesion was not substantial, but a reduction of the erythroid component was observed along with histopathological improvement of dysplasia with a P value of 0.01. Conclusion: Comparatively, bleomycin was more efficient in producing clinical and histopathologic resolution of OL than curcumin.
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