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ORIGINAL ARTICLE
Year : 2022  |  Volume : 34  |  Issue : 4  |  Page : 390-393

Evaluating the role of salivary oxidative stress marker malondialdehyde in dental caries—A comparative study


Department of Oral Pathology and Microbiology, SRM Dental College, Chennai, Tamil Nadu, India

Correspondence Address:
Amritha James
Department of Oral Pathology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai - 600 089, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.jiaomr_109_22

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Introduction: Free radical-induced damage on the lipids results in the creation of a novel oxidative stress marker—malondialdehyde (MDA). MDA-induced cell damage affects the immune mechanisms of saliva and may lead to the initiation and progression of bacterial diseases like periodontitis and even dental caries. Aim and Objectives: To determine the salivary levels of the oxidative stress marker—malondialdehyde (MDA) in subjects with dental caries before and after treatment to assess the role of MDA in the initiation and evolution of dental caries. Materials and Methods: The study included 40 patients in total. Based on the number of caries teeth present at the time of diagnosis, patients were divided into two groups: Group I: Subjects with dental caries in 1–2 teeth, N = 20; Group II: Subjects with dental caries in 3–4 teeth, N = 20. The patients were further divided into two groups after undergoing treatment: Group III: Group I subjects who undertook treatment for dental caries, N = 20; Group IV: Group II subjects who underwent treatment for dental caries, N = 20. The whole saliva was obtained from all subjects before treatment and one month after treatment. Estimation of MDA levels was done using ELISA. Statistical analysis was conducted using Student's t-test and Pearson's correlation coefficient. A P value ≤ 0.05 was considered significant. Results: Elevated levels of MDA were evident in subjects with greater carious lesions. The levels of MDA decreased significantly in post-treatment subjects. Pearson's correlation analysis also showed a strong positive correlation with the R-value of 0.832 between Group I and Group II. Conclusion: MDA levels increased with an increase in carious lesions and significantly reduced following treatment proving the role of salivary MDA in the evolution of dental caries.


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