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ORIGINAL ARTICLE
Year : 2022  |  Volume : 34  |  Issue : 4  |  Page : 380-384

Estimation of Malondialdehyde Levels and Determination of Total Antioxidant Capacity in Serum and Saliva of Patient Affected with Sickle Cell Anemia


1 Department of Oral Medicine and Radiology, Baba Jaswant Singh Dental College, Hospital and Research Institute, Ludhiana, Punjab, India
2 Department of Oral Medicine and Radiology, Triveni Institute of Dental Science, Hospital and Research Centre, Bilaspur, Chhattisgarh, India
3 Department of Pediatric Medicine, Christian Medical College and Hospital, Ludhiana, Punjab, India
4 Department of General Medicine, Baba Jaswant Singh Dental College, Hospital and Research Institute, Ludhiana, Punjab, India

Correspondence Address:
Megha Bahal
B34-5615 Raghubir Park, Jassian Road, Haibowal Kalan, Ludhiana, Punjab - 141 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.jiaomr_146_22

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Introduction: Hemoglobinopathy is an inherited blood disorder in which an individual has an abnormal form of hemoglobin (variant) or decreased production of hemoglobin. The molecular pathogenesis of sickle cell disease explains the phenomenon well when there is adeficiency of oxygen carriage by the erythrocytes. The horrendous patterns of sickling/unsickling bring about the accumulation of lipid oxidation items and reactive oxygen speciesthat gather inside sickle-shaped red blood cells (RBCs). Aims: To estimate the malondialdehyde levels and determine the total antioxidant capacity in serum and saliva of sickle cell anemic patients. Methods and Material: Fiftysubjects aged 5–40 years were selected for the study. The subjects were divided into two groups. Blood and saliva samples were collected from both groups and were subjected to the phosphomolybdenum method. Absorbance was read spectrophotometrically at 695 nm. SPSS software was used, and statistical analysis was performed using Student's unpaired ttests. Results: Oxidative stress results f an imbalance between reactive oxygen species formation and enzymatic and non-enzymatic antioxidants. Conclusion: Salivary levels of total antioxidant capacity, malondialdehyde, and electrolytes make saliva a potential prognostic and diagnostic medium as there is an alteration of oxidative stress in sickle cell anemia (SCA).


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