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ORIGINAL ARTICLE
Year : 2022  |  Volume : 34  |  Issue : 2  |  Page : 136-140

Comparative evaluation of the efficacy of topical Amlexanox 5%, Triamcinolone Acetonide 0.1%, and Tacrolimus 0.03% in the treatment of oral erosive lichen planus – A double-blinded randomized clinical trial


1 Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India
2 Private Practitioner, Bhatkal, Karnataka, India
3 Department of Oral Medicine and Radiology, Subharti Dental College, Meerut, India
4 Department of Public Health Dentistry, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India

Correspondence Address:
Vaibhav Seth
Senior Lecturer, Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre, Moradabad - 244 001, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.jiaomr_16_21

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Objective: The objective of this study was to evaluate the short-term efficacy and safety of the topical application of amlexanox paste with triamcinolone acetonide paste and tacrolimus paste in the treatment of oral erosive lichen planus. Study Design: This study was a randomized double-blinded placebo-controlled clinical trial. Forty patients aged 18–70 years with erosive oral lichen planus received amlexanox 5% paste (n = 10), triamcinolone acetonide 0.1% paste (n = 10), tacrolimus 0.03% paste (n = 10), and glycerin as placebo (n = 10) for 15 days. Outcome measures included pain using visual analog scale (VAS) scores, and the erosive area in cm2 was evaluated both before (baseline) and during the trial (i.e., days 7 and 15). Results: After 15 days of treatment, all the groups showed significant reductions in erosive areas and VAS scores (P <.001) except for the glycerin-treated group, where it was found to be non-significant. No systemic side effects and adverse reactions were observed in the present study. Conclusion: It was found that the topical application of 5% amlexanox paste appeared as effective as 0.1% triamcinolone acetonide paste and 0.03% tacrolimus paste in the treatment of oral erosive lichen planus.


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