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Year : 2021  |  Volume : 33  |  Issue : 3  |  Page : 248-251

Analysis of downregulated salivary proteins in oral submucous fibrosis – A quantitative proteomic pilot study

Department of Oral Medicine and Radiology, Yenepoya Dental College, Mangalore, Karnataka, India

Correspondence Address:
Dr. Anu Babu
Department of Oral Medicine and Radiology, Yenepoya Dental College, Yenepoya University, Derlakkate, Mangalore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jiaomr.jiaomr_59_21

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Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity which is strongly associated with chewing of areca nut. The rate of malignant transformation varies between 3% and 19%. As oral lesions are in direct contact with saliva, the altered composition of saliva has shown promising results in surveillance of malignant transformation. Aim: To do quantitative proteomic profiling of saliva in OSMF and to study the downregulated proteins. Methodology: Quantitative proteomic profiling was carried out using Liquid chromatography with Tandem mass spectroscopy (LC–MS/MS) on saliva obtained from patients with OSMF. Results: A total of 172 proteins were identified in saliva samples. Five proteins were downregulated in the samples (fold change average of disease vs. control ratio ≤0.6). Conclusion: Downregulated proteins could serve as potential biomarkers in the early detection of malignant transformation in OSMF.

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