Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study

Anand Choudhary; Pallavi Kesarwani; Pravin Gaikwad; Santhosh S Hiremath; Renuka Gupta; Sri Krishna Koppula

doi:10.4103/0972-1363.195099

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ORIGINAL ARTICLE

Year : 2016 | Volume : 28 | Issue : 2 | Page : 140-144

Expression of cyclin D1 in oral squamous cell carcinoma and its correlation with histological differentiation: An immunohistochemical study

Anand Choudhary¹, Pallavi Kesarwani², Pravin Gaikwad³, Santhosh S Hiremath⁴, Renuka Gupta⁵, Sri Krishna Koppula¹
¹ Department of Oral Medicine and Radiology, Hazaribag College of Dental Sciences, Hazaribag, Jharkand, India
² Department of Oral Pathology and Microbiology, Hazaribag College of Dental Sciences, Hazaribag, Jharkand, India
³ Department of Oral Pathology and Microbiology, Sukhmani Dental College, Dera Bassi, Punjab, India
⁴ Department of Oral Pathology and Microbiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India
⁵ Department of Oral Pathology and Microbiology, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India

Correspondence Address:
Pallavi Kesarwani
Flat No. 2A Savitri Appartment, Harihar Singh Road, Morabadi, Ranchi - 834 008, Jharkhand
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0972-1363.195099

Introduction: Cyclin D1 oncogene is a key regulator of cell cycle progression associated with various human malignancies. Aim: To establish the prognostic significance of cyclin D1 in oral squamous cell carcinoma (OSCC) and to correlate its association with clinicopathological parameters. Materials and Methods: A retrospective study was carried out on 50 previously histopathologically diagnosed, formalin-fixed, paraffin embedded (FFPE) tissue samples of OSCC. Immunohistochemical analysis was performed in 50 cases of different grades of OSCC using a commercially available monoclonal anti-cyclin D1 antibody. Statistical Analysis Used: All the compiled data was statistically analyzed using Chi-square and Mann-Whitney test. P values of <0.05 were considered to be significant. Results: Overexpression of cyclin D1 was seen in 68% cases of OSCC with a significant correlation with younger age group; no correlation was reported with respect to gender and site. The intergroup comparison of the cyclin D1 expression between well with poorly differentiated OSCC exhibited a significant correlation. Conclusions: The relative contribution of cyclin D1 expression in OSCC was significant according to the present study and further needs to be determined in large cohorts.

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