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ORIGINAL ARTICLE
Year : 2015  |  Volume : 27  |  Issue : 1  |  Page : 29-34

Evaluation of serum lactate dehydrogenase in oral squamous cell carcinoma, oral leukoplakia and oral submucous fibrosis


1 Department of Oral Medicine and Radiology, Index Institute of Dental Science, Indore, Madhya Pradesh, India
2 Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Atul Rathore
Department of Oral Medicine and Radiology, Index Institute of Dental Science, Indore - 452 009, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-1363.167071

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Introduction: Enzyme lactate dehydrogenase (LDH) is found in cells of almost all body tissues. Lactate dehydrogenase activity in serum increases as a marker of cellular necrosis. Serum LDH levels have been used as an adjunct biochemical marker in diagnosis in various pre-cancer and cancers. Aims and Objectives: To evaluate role of LDH as a biochemical parameter in the diagnosis of oral squamous cell carcinoma (OSCC), oral leukoplakia (OL) and oral submucous fibrosis (OSMF), to assess the levels of serum LDH in OSCC, OL and OSMF and to compare the same with normal individuals. Materials and Methods: A total of 120 patients were recruited for the study including 30 patients of OSCC, 30 patients of OL, 30 patients of OSMF and 30 normal controls. All were divided into age groups (20-60 years) irrespective of sex. From five milliliters of blood drawn under aseptic conditions, the serum was separated. The sample was subjected to biochemical analysis for quantitative estimation of serum LDH by a semi auto-analyzer. Results: It was observed that serum LDH activity was significantly (P < 0.05) increased in patients with OSCC, OL and OSMF. Conclusion: Serum LDH estimation can prove to be a valuable tool as a biochemical marker as it is a simple, non-invasive procedure and is easily accepted by the patient.


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