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Year : 2014  |  Volume : 26  |  Issue : 1  |  Page : 8-12

A case-control study to evaluate salivary cortisol levels in patients with dry mouth

1 Department of Oral Medicine and Radiology, Indira Gandhi Institute of Dental Sciences, Puducherry, India
2 Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India

Correspondence Address:
Vandana Shekar
Department of Oral Medicine and Radiology, Indira Gandhi Institute of Dental Sciences, MGMC and RI Campus, Pillaiyarkuppam - 607 402, Puducherry
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-1363.141824

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Objective: The purpose of this study is to evaluate the salivary cortisol levels in patients with dry mouth. Materials and Methods: The study population consisted of 20 patients with a complaint of dry mouth and 20 asymptomatic age- and sex-matched controls. In patients who complained of dry mouth, the salivary flow rate (ml/minute) was estimated by measuring the quantity of the saliva collected in the collector. The concentration of cortisol in the saliva (΅g/dl) was determined by using a salivary enzyme-linked immunoassay (ELISA) kit. Statistical Analysis: The results were evaluated using the Student's t-test. Results: There was only a mild increase in salivary cortisol in both stimulated and unstimulated saliva in patients with dry mouth compared to the controls (p-value 0.981 and 0.481, respectively), which was not statistically significant. Conclusion: There may not be a clear association between the salivary cortisol level and dry mouth. In older individuals, age-associated salivary gland hypofunction and life changes may be the main risk factors for dry mouth compared to stress and anxiety.

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