| RESEARCH |
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| Year : 2012 | Volume
: 24
| Issue : 2 | Page : 102-105 |
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Genetic damage in exfoliated cells from oral mucosa of individuals exposed to x-rays after panoramic radiograph: A cross-sectional study
Ramalakshmi Madhavan1, Manikandan Kumaraswamy2, S Kailasam3, S Manoj Kumar4
1 Lecturer, Department of Oral Medicine and Radiology Sri Venkateshwara Dental College, Chennai, Tamil Nadu, India
2 Reader, Department of Prosthodontics, Sri Venkateshwara Dental College, Chennai, Tamil Nadu, India
3 Professor and Head, Department of Oral Medicine and Radiology Ragas Dental College and Hospital, Chennai, Tamil Nadu, India
4 Professor, Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India
Correspondence Address:
Ramalakshmi Madhavan
Lecturer, Department of Oral Medicine and Radiology Sri Venkateshwara Dental College, Chennai, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.5005/jp-journals-10011-1271
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Objectives: In the past decades, X-rays have been used widely for diagnosis in dentistry. However, it is well known that ionizing radiation causes damage (including single- and double-strand breaks) to deoxyribonucleic acid (DNA) and DNA-protein crosslinks, and induces cellular death. Therefore, outlining the cytogenetic effects induced by X-ray is necessary to identify the degree of cancer risk and minimize potential risks to patients and clinicians.
Materials and methods: Cytogenetic biomonitonng studies focusing on oral mucosa cells in individuals exposed to dental X-ray were reviewed.
Results: Dental X-ray can induce DNA damage and cytotoxicity in oral mucosa cells.
Conclusion: These results will contribute to a better understanding of X-ray-induced effects upon the cellular system in individuals continually exposed to known genotoxic/cytotoxic agents.
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