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CLINICAL REVIEW
Year : 2007  |  Volume : 19  |  Issue : 1  |  Page : 248-255

Paget's Disease - Report of two cases with Review of literature


Department of Oral Medicine & Radiology, Ragas Dental College & Hospital, Uthandi, Chennai, India

Correspondence Address:
S Shanmugam
Department of Oral Medicine & Radiology, Ragas Dental College & Hospital, Uthandi, Chennai
India
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Source of Support: None, Conflict of Interest: None


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Paget's disease is a chronic, progressive disturbance in bone metabolism characterized by an initial phase of deossification and softening, followed by a bizarre, dysplastic type of reossification not related to functional requirements. .The two processes may take place simultaneously or they may alternate. In early phases of disease, resorption is usually more prominent but in the advanced stages a typical osteogenesis becomes increasingly pronounced, resulting in the progressive enlargement and deformity of affected bones. The etiology is unknown, though recently it has been thought to be related to a slow virus infection. It occurs over 40 years of age with a male preponderance of 3:2. It affects almost all bones and in the jaws, maxilla is more commonly affected than mandible. A few complications of Paget's disease include pathologic fracture, osteomyelitis, osteosarcoma. We report two cases of Paget's disease of bone. One case with unilateral monostotic involvement of maxilla and other with a complete spectrum of the disease affecting all bones. A special point of interest in the first case is osteomyelitis complicating Paget's disease of maxilla.


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